1928 ⟶ Diels-Alder Reaction: Cycloaddition for Ring Molecule Formation

Otto Diels and Kurt Alder discovered the Diels-Alder cycload...
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Year
1757
1865
1928
1929
1937

⚗️ Cadet de Gassicourt Creates Cacodyl Oxide

Louis Claude Cadet de Gassicourt, while investigating arsenic compounds, creates Cadet's fuming liquid, later discovered to be cacodyl oxide, considered to be the first synthetic organometallic compound.⟶
Cadet de Gassicourt Creates Cacodyl Oxide (1757)
ChemistryOrganic ChemistryOrganometallic ChemistryCadet's Fuming LiquidLouis Claude Cadet de GassicourtSynthetic Chemistry18th Century
FranceFrance

⚛️ Kekulé's Discovery of Benzene Ring Structure

Friedrich August Kekulé von Stradonitz realized that benzene is composed of carbon and hydrogen atoms in a hexagonal ring.⟶
Kekulé's Discovery of Benzene Ring Structure (1865)
ChemistryOrganic ChemistryKekuléBenzeneMolecular Structure19th CenturyStructural FormulaChemical Bonding
GermanyGermany

⚛️ Diels-Alder Reaction: Cycloaddition for Ring Molecule Formation

Otto Diels and Kurt Alder discovered the Diels-Alder cycloaddition reaction for forming ring molecules.⟶
Diels-Alder Reaction: Cycloaddition for Ring Molecule Formation (1928)
ChemistryOrganic ChemistryChemical ReactionCycloadditionDiels-Alder ReactionSynthetic ChemistryMolecular Structure20th Century
GermanyGermany

🧪 Edward Doisy and Adolf Butenandt Independently Discover Estrone

Edward Doisy and Adolf Butenandt independently discovered estrone.⟶
Edward Doisy and Adolf Butenandt Independently Discover Estrone (1929)
ChemistryBiochemistryHormonesEstroneEndocrinologyEdward DoisyAdolf Butenandt20th CenturySteroid Chemistry
United StatesUnited StatesGermanyGermany

🔬 Linus Pauling Publishes Pauling's Rules for X-ray Crystallography

Linus Pauling publishes Pauling's rules, which are key principles for the use of X-ray crystallography to deduce molecular structure.⟶
Linus Pauling Publishes Pauling's Rules for X-ray Crystallography (1929)
ChemistryX-ray CrystallographyMolecular StructureLinus PaulingPauling's RulesCrystallographyStructural Chemistry20th Century
United StatesUnited States

🧬 Dorothy Crowfoot Hodgkin discovers the three-dimensional structure of cholesterol

Dorothy Crowfoot Hodgkin discovered the three-dimensional structure of cholesterol.⟶
Dorothy Crowfoot Hodgkin discovers the three-dimensional structure of cholesterol (1937)
BiochemistryX-ray CrystallographyDorothy Crowfoot HodgkinCholesterolOrganic ChemistryStructure Determination20th CenturyMolecular Structure
United KingdomUnited Kingdom